Animal Residue Data Sheet - Spinosad
11 June 2003
Spinosad is registered in Australia for use on cotton, brassica vegetables, grapes, pome fruit, tomatoes, capsicum, peppers, lettuce, spinach and sweet corn. Spinosad is present in registered veterinary formulations for use on sheep. Details of the registered use patterns can be found on the approved labels of registered products containing spinosad as the active constituent. This Animal Residue Data Sheet provides information on the possible residues in feed commodities obtained from crops treated with spinosad. It also provides information on the anticipated maximum dietary exposure of animals fed treated commodities which should not result in the violation of animal MRLs.
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Current MRLs
The Australian MRLs for spinosad in food and animal feed commodities, as listed in Table 1 and Table 4 of the MRL Standard [as at 12 March 2003] are shown below. The residue definition of spinosad is the "Sum of spinosyn A and spinosyn D".
| Code | Food | Current MRL, mg/kg |
|---|---|---|
| Food Commodities | ||
| FI 0030 | Assorted tropical and sub-tropical fruits —inedible peel | T0.5 |
| VP 0061 | Beans, except broad bean and soybeans | T0.2 |
| Bergamot | T5 | |
| FB 0018 | Berries and other small fruit [excluding grapes] | T0.5 |
| VB 0040 | Brassica (cole or cabbage) vegetables, head cabbages, flowerhead brassicas | 0.5 |
| VS 0624 | Celery | T*0.25 |
| FC 0001 | Citrus fruits | T0.1 |
| VL 0465 | Chervil | T5 |
| Coriander (leaves, stems, roots) | T5 | |
| HS 0779 | Coriander seed | T5 |
| SO 0691 | Cotton seed | *0.01 |
| HS 0730 | Dill seed | T5 |
| VO 0440 | Egg plant | T0.1 |
| HS 0731 | Fennel seed | T5 |
| VR 0581 | Galangal, greater | T*0.01 |
| FB 0269 | Grape | 0.5 |
| HH 0092 | Herbs | T5 |
| Kaffir lime leaves | T5 | |
| VL 0053 | Leafy vegetables | 5 |
| Lemon grass | T5 | |
| DT 1111 | Lemon verbena (dry leaves) | T5 |
| VC 0046 | Melons, except watermelon | T0.2 |
| Mizuna | T5 | |
| VP 0063 | Peas | T0.2 |
| VO 0051 | Peppers | 0.2 |
| FP 0009 | Pome fruit | 0.2 |
| VR 0589 | Potato | T*0.01 |
| VD 0070 | Pulses | T*0.01 |
| VL 0496 | Rucola (rocket) | T5 |
| Salad burnett | T5 | |
| GC 0651 | Sorghum | T*0.01 |
| FS 0012 | Stone fruit | T0.2 |
| VO 0447 | Sweet corn (corn-on-the-cob) | 0.02 |
| VO 0448 | Tomato | 0.2 |
| TN 0085 | Tree nuts | T*0.01 |
| HS 0794 | Tumeric, root | T*0.01 |
| Animal commodities | ||
| MO 0105 | Edible offal (mammalian) | 0.05 |
| PE 0112 | Eggs | T0.05 |
| MM 0095 | Meat (mammalian) [in the fat] | 0.2 |
| ML 0106 | Milks | 0.02 |
| PO 0111 | Poultry, Edible offal of | T0.05 |
| Poultry fat/skin | T0.2 | |
| PM 0110 | Poultry meat | *0.01 |
| Animal Feed Commodities | ||
| AB 0226 | Apple pomace, dry | 1 |
| Grape pomace | 1 (dry wt basis) | |
| Cottonseed by-products | *0.01 | |
| AL 0157 | Legume animal feeds | T0.05 |
| AF 0651 | Sorghum forage (green) | T0.05 |
| AS 0651 | Sorghum straw and fodder, dry | T0.05 |
Summary of Maximum Feeding Levels and Livestock Dietary Intakes
(Note that all calculations have been performed using the proposed new MRLs and MFLs, where applicable.)
The Maximum Feeding Level (MFL, the feeding level at which the MRLs are based), the equivalent Daily Dietary Intake for Livestock (DDIL) and the equivalent daily intake of spinosad are summarised below.
| Species | MFL, ppm in diet | Equivalent DDIL, mg/kg bw | Equivalent intake of spinosad, mg/animal/day |
|---|---|---|---|
| Cattlea | 0.56 | 0.012 | 5.45 |
| Sheepb | 0.56 | 0.023 | 1.4 |
| Pigc | 0.56 | 0.023 | 1.4 |
| Poultryd | 1.0 | 0.075 | 0.15 |
|
aBased on animal transfer study b Based on a 60 kg animal consuming 2.5 kg DM/day c Based on a 60 kg animal consuming 2.5 kg DM/day d Based on animal transfer study |
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Detailed Information
All Feed Commodities
Feed commodities that may contain residues of spinosad are listed in the table below. The theoretical maximum proportion of the diet that the commodity can compose, when residues are present at the MRL, without the significant risk of animal commodity MRLs being violated is also given. For instance, were apple pomace to be fed to cattle at 50% of the diet, the remainder of the diet would need to be free of residues of spinosad to minimise the risk of cattle commodity MRLs being violated. It should be noted that the feeding levels assumed by the NRA when setting animal commodity MRLs are theoretical values, and they should not be taken as recommendations of appropriate rations for livestock.
| Commodity a | Assumed Maximum proportion of diet (%)b | Feed intake (kg/animal/day)c | MRLdor
STMR-Pe (mg/kg) |
Maximum intake of spinosad from commodity (mg/animal/day)f | Theoretical maximum proportion of diet (%)g |
|---|---|---|---|---|---|
| Cattle (Based on a 500 kg animal consuming 20 kg DM/day) | |||||
| Cotton seed | 30 | 6 | 0.01d | 0.06 | 100 |
| Cotton seed meal and hulls | 30 | 6 | 0.01d | 0.06 | 100 |
| Apple pomace, dry | 20 | 4 | 0.57e | 2.28 | 48 |
| Grape pomace, dry | 20 | 4 | 0.47e | 1.88 | 58 |
| Sheep (Based on a 60 kg animal consuming 2.5 kg DM/day) | |||||
| Cotton seed | 30 | 0.75 | 0.01d | 0.0075 | 100 |
| Cotton seed meal and hulls | 20 | 0.5 | 0.01d | 0.005 | 100 |
| Apple pomace, dry | 20 | 0.5 | 0.57e | 0.285 | 98 |
| Grape pomace, dry | 20 | 0.5 | 0.47e | 0.235 | 100 |
| Pigs (Based on a 60 kg animal consuming 2.5 kg DM/day) | |||||
| Cotton seed | 30 | 0.75 | 0.01d | 0.0075 | 100 |
| Cotton seed meal and hulls | 30 | 0.75 | 0.01d | 0.0075 | 100 |
| Apple pomace, dry | 20 | 0.5 | 0.57e | 0.285 | 98 |
| Grape pomace, dry | 20 | 0.5 | 0.47e | 0.235 | 100 |
| Poultry (Based on a 2 kg animal consuming 150 g DM/day) | |||||
| Cotton seed | 20 | 0.03 | 0.01d | 0.0003 | 100 |
| Cotton seed meal and hulls | 20 | 0.03 | 0.01d | 0.0003 | 100 |
| Apple pomace, dry | 5 | 0.0075 | 0.57e | 0.0043 | 100 |
| Grape pomace, dry | 5 | 0.0075 | 0.47e | 0.0035 | 100 |
|
a
The feed commodities that may contain residues of spinosad, and
may form more than 20% of an animals diet. b The maximum % of the diet that the commodity is assumed to comprise for the purposes of setting MRLs, based on Stockfeed Information Document 1 c The equivalent amount of feed for an animal of designated weight and feed intake that is assumed for the purposes of setting MRLs d The MRL for each feed commodity (correction for dry weight basis where required)e.The STMR-P for each feed commodity (correction for dry weight basis where required) f The maximum intake of spinosad when the commodity is fed at the maximum assumed level (Column 1) in the absence of other sources of spinosad. g The maximum % of the diet at which the commodity could theoretically be fed without significant risk of exceeding animal commodity MRLs. It is assumed that the residue in the feed commodity is present at the MRL (or dry weight equivalent) and other dietary sources of spinosad are absent. |
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Abbreviations and Definitions
DM: Dry matter. The feed consumption for livestock and the residue levels in feed commodities are expressed on a dry matter basis.
DDIL: Daily Dietary Intake for Livestock. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in mg chemical/kg bodyweight.
MFL: Maximum Feeding Level. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in terms of ppm in the feed.
MRL: The concentration of a chemical residue, in units of mg/kg, that is legally permitted in or on a food or food commodity.
ppm in the feed: Parts per million in the feed. An alternate way of expressing the level of dietary exposure for a chemical. The level of chemical intake is calculated as though it were present uniformly in the total feed intake. For example: a cow consumes 10 kg of grain containing 10 mg/kg of Chemical X and 10 kg of apple pomace containing 5 mg/kg of Chemical X. The total intake of Chemical X is 150 mg in 20 kg of feed. This is equivalent to 7.5 ppm in the feed [150÷20].
STMR-P: Supervised Trial Median Residue of the processed commodity. The highest residue that livestock are likely to be exposed to in practice when fed processed commodities over a prolonged period. This is derived from the STMR of the whole commodity multiplied by the processing factor.
Attachment 1: Anticipated Maximum Dietary Exposure
The following calculations outline the theoretical diet used to calculate the maximum anticipated dietary exposure, maximum feeding level (MFL) and the daily dietary intake for livestock (DDIL) for cattle, sheep, pigs and poultry.
Cattle
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL/STMR-P, mg/kg | % DMb | Intake of spinosad, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fruit by-products[20 % maximum] | Apple pomace, dry | 20 | 4 | 0.57 | -- | 2.28 |
| Oilseeds[30 % maximum] | Cotton seed / by-products | 30 | 6 | 0.01 | -- | 0.06 |
| Total | 50 | 10 | 2.34 | |||
|
aBased on assumed feed consumption of 20 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 500 kg |
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| Maximum anticipated dietary exposure: | 2.34 mg/animal/day |
|---|---|
| Equivalent to: | 0.005 mg/kg bw |
| Equivalent to: | 0.12 ppm in the diet |
| MFL (beef cattle data) | 0.56 ppm in the diet |
| Equivalent DDIL: | 0.012 mg/kg bw |
Sheep
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL/STMR-P, mg/kg | % DMb | Intake of spinosad, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fruit by-products[20 % maximum] | Apple pomace, dry | 20 | 0.5 | 0.57 | -- | 0.2850 |
| Oilseeds[30 % maximum] | Cotton seed | 30 | 0.75 | 0.01 | -- | 0.0075 |
| Total | 50 | 1.25 | 0.2925 | |||
|
aBased
on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg |
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| Maximum anticipated dietary exposure: | 0.2925 mg/animal/day |
|---|---|
| Equivalent to: | 0.005 mg/kg bw |
| Equivalent to: | 0.12 ppm in the diet |
| MFL (Based on extrapolation of cattle data) | 0.56 ppm in the diet |
| Equivalent DDIL: | 0.023 mg/kg bw |
Pigs
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL/STMR-P, mg/kg | % DMb | Intake of spinosad, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fruit by-products[20 % maximum] | Apple pomace, dry | 20 | 0.5 | 0.57 | -- | 0.2850 |
| Oilseeds[30 % maximum] | Cotton seed / by-products | 30 | 0.75 | 0.01 | -- | 0.0075 |
| Total | 50 | 1.25 | 0.2925 | |||
|
aBased on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg |
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| Maximum anticipated dietary exposure: | 0.2925 mg/animal/day |
|---|---|
| Equivalent to: | 0.005 mg/kg bw |
| Equivalent to: | 0.12 ppm in the diet |
| MFL (Based on extrapolation of cattle data): | 0.56 ppm in the diet |
| Equivalent DDIL: | 0.023 mg/kg bw |
Poultry
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL/STMR-P, mg/kg | % DMb | Intake of spinosad, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fruit by-products[5 % maximum] | Apple pomace, dry | 5 | 0.0075 | 0.57 | -- | 0.0043 |
| Oilseeds[30 % maximum] | Cotton seed / by-products | 20 | 0.03 | 0.01 | -- | 0.0003 |
| Total | 25 | 0.03575 | 0.0046 | |||
|
aBased on assumed feed consumption of 0.150 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 2 kg |
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| Maximum anticipated dietary exposure: | 0.0046 mg/animal/day |
|---|---|
| Equivalent to: | 0.0023 mg/kg bw |
| Equivalent to: | 0.03 ppm in the diet |
| MFL (Based on animal transfer data): | 1.0 ppm in the diet |
| Equivalent DDIL: | 0.075 mg/kg bw |