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Animal Residue Data Sheet - Kresoxim-methyl

Kresoxim-methyl is registered in Australia for use on apples. Details of the registered use patterns can be found on the approved labels of registered products containing kresoxim-methyl as the active constituent. This Animal Residue Data Sheet provides information on the possible residues in feed commodities obtained from crops treated with kresoxim-methyl. It also provides information on the anticipated maximum dietary exposure of animals fed treated commodities, which should not result in the violation of animal MRLs.

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Current MRLs

The Australian MRLs for kresoxim-methyl in food and animal feed commodities, as listed in Table 1 and Table 4 of the MRL Standard (as at August 2002) are shown below. The residue definition of kresoxim-methyl is the following:
Commodities of plant origin: Kresoxim-methyl
Commodities of animal origin: sum of α-(p-hydroxy-o-tolyloxy)-o-tolyl(methoxyimino) acetic acid and (E)-methoxyimino[α-(o-tolyloxy)-o-tolyl] acetic acid, expressed as kresoxim-methyl

Code Food MRL, mg/kg
Food Commodities
FP 0226 Apple 0.1
Animal commodities
MO 0105 Edible offal (mammalian) *0.01
MM 0095 Meat (mammalian) *0.01
ML 0106 Milks *0.001
Animal feed commodities
AB 0226 Apple pomace, dry 0.5

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Summary of Maximum Feeding Levels and Livestock Dietary Intakes

The Maximum Feeding Level (MFL, the feeding level at which the MRLs are based), the equivalent Daily Dietary Intake For Livestock (DDIL) and the equivalent daily intake of kresoxim-methyl are summarised below.

Maximum Feeding Level, equivalent Daily Dietary Intake for Livestock (DDIL) and the equivalent daily intake of kresoxim-methyl
Species MFL, ppm in diet Equivalent DDIL, mg/kg bw Equivalent intake of kresoxim-methyl, mg/animal/day
Cattlea 7 0.28 120
Sheepb 7 0.29 17.5
Pigc 7 0.29 17.5
Poultryd N/A    
a Based on dairy cow animal feeding study
b Based on a 60 kg animal consuming 2.5 kg DM/day
c Based on a 60 kg animal consuming 2.5 kg DM/day
d Based on a 2 kg animal consuming 150 g DM/day

N/A = not applicable. There are no MRLs established for poultry commodities. Apple pomace is not considered a major feed component for poultry.

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Detailed Information

All feed commodities

Feed commodities that may contain residues of kresoxim-methyl are listed in the table below. The theoretical maximum proportion of the diet that the commodity can compose, when residues are present at the MRL, without the significant risk of animal commodity MRLs being violated is also given. In this case, apple pomace may be fed to cattle up to 100 % of the diet with minimal risk of cattle commodity MRLs being violated. It should be noted that the feeding levels assumed by the APVMA when setting animal commodity MRLs are theoretical values, and they should not be taken as recommendations of appropriate rations for livestock.

Commodity a Assumed Maximum proportion of diet (%)b Feed intake (kg/animal/day)c STMR-P (mg/kg) d Maximum intake of kresoxim-methyl from commodity (mg/animal/day)e Theoretical maximum proportion of diet (%)f
Cattle (Based on a 500 kg animal consuming 20 kg DM/day)
Apple pomace, dry 20 4 0.18 0.72 100
Sheep (Based on a 60 kg animal consuming 2.5 kg DM/day)
Apple pomace, dry 20 0.5 0.18 0.09 100
Pigs (Based on a 60 kg animal consuming 2.5 kg DM/day)
Apple pomace, dry 20 0.5 0.18 0.09 100

a The feed commodities that may contain residues of kresoxim-methyl, and may form more than 20% of an animals diet.
b The maximum % of the diet that the commodity is assumed to comprise for the purposes of setting MRLs, based on Stockfeed Information Document 1
c The equivalent amount of feed for an animal of designated weight and feed intake that is assumed for the purposes of setting MRLs
d The STMR-P for each feed commodity (correction for dry weight basis where required)
e The maximum intake of kresoxim-methyl when the commodity is fed at the maximum assumed level (Column 1) in the absence of other sources of kresoxim-methyl.
f The maximum % of the diet at which the commodity could theoretically be fed without significant risk of exceeding animal commodity MRLs. It is assumed that the residue in the feed commodity is present at the MRL (or dry weight equivalent) and other dietary sources of kresoxim-methyl are absent.

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Abbreviations and Definitions

DM: Dry matter. The feed consumption for livestock and the residue levels in feed commodities are expressed on a dry matter basis.

DDIL: Daily Dietary Intake for Livestock. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in mg chemical/kg bodyweight.

MFL: Maximum Feeding Level. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in terms of ppm in the feed.

MRL: The concentration of a chemical residue, in units of mg/kg, that is legally permitted in or on a food or food commodity.

ppm in the feed: Parts per million in the feed. An alternate way of expressing the level of dietary exposure for a chemical. The level of chemical intake is calculated as though it were present uniformly in the total feed intake. For example: a cow consumes 10 kg of grain containing 10 mg/kg of chemical Y and 10 kg of apple pomace containing 5 mg/kg of Chemical Y. The total intake of Chemical Y is 150 mg in 20 kg of feed. This is equivalent to 7.5 ppm in the feed [150÷20].

STMR-P: Supervised Trial Median Residue of the processed commodity. The highest residue that livestock are likely to be exposed to in practice when fed processed commodities over a prolonged period. This is derived from the STMR of the whole commodity multiplied by the processing factor.

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Attachment 1: Anticipated Maximum Dietary Exposure

The following calculations outline the theoretical diet used to calculate the maximum anticipated dietary exposure, maximum feeding level (MFL) and the daily dietary intake for livestock (DDIL) for cattle, sheep, pigs and poultry.

Cattle

Feed group Feed commodity % in the diet Feed intake, kg/animal/daya MRL, mg/kg % DMb Intake of kresoxim-methyl, mg/animal/dayc
Fruit by-products
[20 % maximum]		 Apple pomace, dry 20 4 0.5 - 2
Total   20     2

aBased on assumed feed consumption of 20 kg dry matter/day
bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis
cBased on assumed bodyweight of 500 kg

Maximum anticipated dietary exposure: 2 mg/animal/day
Equivalent to: 0.004 mg/kg bw
Equivalent to: 0.1 ppm in the diet
MFL (Based on the available animal feeding data (Attachment 2)): 7 ppm in the diet
Equivalent DDIL: 0.28 mg/kg bw

Sheep

Feed group Feed commodity % in the diet Feed intake, kg/animal/daya MRL, mg/kg % DMb Intake of kresoxim-methyl, mg/animal/dayc
Fruit by-products
[20 % maximum]		 Apple pomace, dry 20 0.5 0.5 - 0.25
Total   20       0.25

aBased on assumed feed consumption of 2.5 kg dry matter/day
bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis
cBased on assumed bodyweight of 60 kg

Maximum anticipated dietary exposure: 0.25 mg/animal/day
Equivalent to: 0.0042 mg/kg bw
Equivalent to: 0.1 ppm in the diet
MFL (Based on extrapolation of dairy cattle feeding study (Attachment 2)): 7 ppm in the diet
Equivalent DDIL: 0.29 mg/kg bw

Pigs

Feed group Feed commodity % in the diet Feed intake, kg/animal/daya MRL, mg/kg % DMb Intake of kresoxim-methyl, mg/animal/dayc
Fruit by-products
[20 % maximum]		 Apple pomace, dry 20 0.5 0.5 - 0.25
Total   20       0.25

aBased on assumed feed consumption of 2.5 kg dry matter/day
bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis
cBased on assumed bodyweight of 60 kg

Maximum anticipated dietary exposure: 0.25 mg/animal/day
Equivalent to: 0.0042 mg/kg bw
Equivalent to: 0.1 ppm in the diet
MFL (Based on extrapolation of dairy cattle feeding study (Attachment 2)): 7 ppm in the diet
Equivalent DDIL: 0.29 mg/kg bw