Animal Residue Data Sheet - Fipronil
Last updated: June 2002
Fipronil is registered in Australia for use on various crops. Details of the registered use patterns can be found on the approved labels of registered products containing fipronil as the active constituent. This Animal Residue Data Sheet provides information on the possible residues in feed commodities obtained from crops treated with fipronil. It also provides information on the anticipated maximum dietary exposure of animals fed treated commodities, which should not result in the violation of animal MRLs.
On this page:
Current MRLs
The Australian MRLs for fipronil in food and animal feed commodities, as listed in Table 1 and Table 4 of the MRL Standard (as at 4 June 2002), are shown below. The residue definition of fipronil is:
Sum of fipronil, the sulphenyl metabolite (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)
phenyl]-4-[(trifluoromethyl) sulphenyl]-1H-pyrazole-3-carbonitrile),
the sulphonyl metabolite (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulphonyl]-1H-pyrazole-3-carbonitrile),
and the trifluoromethyl metabolite (5-amino-4-trifluoromethyl-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile).
| Code | Food | MRL, mg/kg |
|---|---|---|
| Food Commodities | ||
| VS 0621 | Asparagus | T0.5 |
| FI 0030 | Assorted tropical and sub-tropical fruit, inedible peel [except banana] | T*0.01 |
| FI 0327 | Banana | *0.01 |
| Bergamot | T0.1 | |
| FB 0018 | Berries and other small fruit [except wine-grapes and strawberries] | T*0.01 |
| VB 0040 | Brassica (cole or cabbage) vegetables, Head cabbages, Flowerhead brassicas | T0.05 |
| Chervil | T0.1 | |
| FC 0001 | Citrus fruits | T*0.01 |
| Coriander (leaves, stems, roots) | T0.1 | |
| HS 0779 | Coriander seed | T0.1 |
| SO 0691 | Cotton seed | *0.01 |
| OC 0691 | Cotton seed oil, crude | *0.01 |
| HS 0730 | Dill seed | T0.1 |
| HS 0731 | Fennel seed | T0.1 |
| HH 0092 | Herbs | T0.1 |
| Kaffir lime leaves | T0.1 | |
| Lemon grass | T0.1 | |
| DT 1111 | Lemon verbena (fresh weight) | T0.1 |
| Mizuna | T0.1 | |
| VO 0450 | Mushrooms | 0.02 |
| SO 0697 | Peanut | T*0.01 |
| OC 0697 | Peanut oil, crude | T*0.01 |
| TN 0672 | Pecan | T*0.01 |
| VO 0051 | Peppers | T0.1 |
| FP 0009 | Pome fruit | T*0.01 |
| VR 0589 | Potato | *0.01 |
| SO 0495 | Rape seed | *0.01 |
| GC 0649 | Rice | *0.005 |
| VL 0496 | Rucola (rocket) | T0.1 |
| GC 0651 | Sorghum | 0.01 |
| FS 0012 | Stone fruits | T*0.01 |
| GS 0659 | Sugar cane | *0.01 |
| SO 0702 | Sunflower seed | *0.01 |
| VR 0508 | Sweet Potato | T*0.01 |
| FB 1236 | Wine-grapes | T*0.01 |
| Animal commodities | ||
| MO 0105 | Edible offal (mammalian) | 0.02 |
| PE 0112 | Eggs | 0.02 |
| MM 0095 | Meat [mammalian] [in the fat] | 0.1 |
| ML 0106 | Milks | 0.01 |
| PO 0111 | Poultry, Edible offal of | *0.01 |
| PM 0110 | Poultry meat [in the fat] | 0.02 |
| Animal feed commodities | ||
| Pastures (mixed grasses/leguminous)[fresh weight] | 0.02 | |
| AL 0697 | Peanut forage and fodder | 0.01 |
| Rape (canola) forage (green) | *0.01 | |
| Rape (canola) straw and fodder | *0.01 | |
| AS 0649 | Rice straw and fodder, dry | 0.005 |
| AF 0651 | Sorghum forage (green)[fresh weight] | 0.02 |
| Sorghum straw and fodder | *0.01 | |
| AM 0659 | Sugar cane fodder | 0.01 |
| Sunflower forage (green) [fresh weight] | 0.01 | |
Summary of Maximum Feeding Levels and Livestock Dietary Intakes
The Maximum Feeding Level (MFL, the feeding level at which the MRLs are based), the equivalent Daily Dietary Intake For Livestock (DDIL) and the equivalent daily intake of fipronil are summarised below.
| Species | MFL, ppm in diet | Equivalent DDIL, mg/kg bw | Equivalent intake of fipronil, mg/animal/day |
|---|---|---|---|
| Cattlea | 0.04 | 0.0012 | 0.85 |
| Sheepb | 0.04 | 0.0017 | 0.1 |
| Pigb | 0.04 | 0.0017 | 0.1 |
| Poultryc | 0.01 | 0.00065 | 0.000975 |
|
a Based on actual dose levels and feed consumption in cattle study b MFL is based on cattle data as no sheep or pig data available, DDIL is calculated from MFL assuming a 60 kg animal consuming 2.5 kg DM/day c Based on actual dose levels and feed consumption in poultry study |
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Detailed Information
All Feed Commodities
Feed commodities that may contain residues of fipronil are listed in the table below. Note that many of the approved uses of fipronil result in residue levels in animal feeds that are below the limit of analytical determination. The following table includes only feed commodities where there is a reasonable expectation of measurable residues occurring. The theoretical maximum proportion of the diet that the commodity can comprise, when residues are present at the MRL, without the significant risk of animal commodity MRLs being violated is also given. It should be noted that the feeding levels assumed by the APVMA when setting animal commodity MRLs are theoretical values, and they should not be taken as recommendations of appropriate rations for livestock.
| Commodity a | Assumed Maximum proportion of diet (%)b | Feed intake (kg/animal/day)c | MRL
/ HR (mg/kg) d |
Maximum intake of chemical X from commodity (mg/animal/day)e | Theoretical maximum proportion of diet (%)f |
|---|---|---|---|---|---|
| Cattle (Based on a 500 kg animal consuming 20 kg DM/day) | |||||
| Sorghum | 100 | 20 | 0.01 | 0.2 | 100 |
| Pastures (mixed grasses/leguminous)[fresh weight] | 100 | 20 | 0.028 (HR, dry wt) | 0.56 | 100 |
| Peanut forage and fodder | 100 | 20 | 0.01 | 0.2 | 100 |
| Rice straw and fodder, dry | 100 | 20 | 0.005 | 0.1 | 100 |
| Sorghum forage (green)[fresh weight] | 100 | 20 | 0.035 (HR, dry wt) | 0.7 | 100 |
| Sugar cane fodder | 100 | 20 | 0.01 | 0.2 | 100 |
| Sunflower forage (green) | 100 | 20 | 0.01 | 0.2 | 100 |
| Sheep (Based on a 60 kg animal consuming 2.5 kg DM/day) | |||||
| Sorghum | 100 | 2.5 | 0.01 | 0.025 | 100 |
| Pastures (mixed grasses/leguminous)[fresh weight] | 100 | 2.5 | 0.028 (HR, dry wt) | 0.07 | 100 |
| Peanut forage and fodder | 100 | 2.5 | 0.01 | 0.025 | 100 |
| Rice straw and fodder, dry | 100 | 2.5 | 0.005 | 0.0125 | 100 |
| Sorghum forage (green)[fresh weight] | 100 | 2.5 | 0.035 (HR, dry wt) | 0.0875 | 100 |
| Sugar cane fodder | 100 | 2.5 | 0.01 | 0.025 | 100 |
| Sunflower forage (green) | 100 | 2.5 | 0.01 | 0.025 | 100 |
| Pigs (Based on a 60 kg animal consuming 2.5 kg DM/day) | |||||
| Sorghum | 100 | 2.5 | 0.01 | 0.025 | 100 |
| Poultry (Based on a 2 kg animal consuming 150 g DM/day) | |||||
| Sorghum | 100 | 0.15 | 0.01 | 0.0015 | 100 |
|
a
The feed commodities that may contain residues of fipronil, and
may form more than 20% of an animals diet. b The maximum % of the diet that the commodity is assumed to comprise for the purposes of setting MRLs, based on Stockfeed Information Document 1 c The equivalent amount of feed for an animal of designated weight and feed intake that is assumed for the purposes of setting MRLs d The MRL (or other residue level as denoted) for each feed commodity. Corrected for dry weight basis where required e The maximum intake of fipronil when the commodity is fed at the maximum assumed level (Column 1) in the absence of other sources of fipronil. f The maximum % of the diet at which the commodity could theoretically be fed without significant risk of exceeding animal commodity MRLs. It is assumed that the residue in the feed commodity is present at the MRL (or other residue level as noted, corrected for dry weight equivalent) and other dietary sources of fipronil are absent. |
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Abbreviations and Definitions
DM: Dry matter. The feed consumption for livestock and the residue levels in feed commodities are expressed on a dry matter basis.
DDIL: Daily Dietary Intake for Livestock. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in mg chemical/kg bodyweight.
HR: Highest residue. The highest residue value observed in supervised residue trials complying with good agricultural practice.
MFL: Maximum Feeding Level. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in terms of ppm in the feed.
MRL: The concentration of a chemical residue, in units of mg/kg, that is legally permitted in or on a food or animal feed commodity.
ppm in the feed: Parts per million in the feed. An alternate way of expressing the level of dietary exposure for a chemical. The level of chemical intake is calculated as though it were present uniformly in the total feed intake. The ppm in the feed is calculated using the following formula: DDIL (mg chemical/kg bw) X body weight (kg) divided by daily feed intake (kg).
STMR-P: Supervised Trial Median Residue of the processed commodity. The highest residue that livestock are likely to be exposed to in practice when fed processed commodities over a prolonged period. This is derived from the STMR of the whole commodity multiplied by the processing factor.
Attachment 1: Anticipated Maximum Dietary Exposure
The following calculations outline the theoretical diet used to calculate the maximum anticipated dietary exposure, maximum feeding level (MFL) and the daily dietary intake for livestock (DDIL) for cattle, sheep, pigs and poultry.
Cattle
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL, mg/kg | % DMb | Intake of chemical X, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fodder
& forage [100% maximum] |
Sorghum
forage (green) [fresh weight] |
100 | 20 | 0.035 (HR)d | - | 0.7 |
| Total | 100 | 20 | - | - | 0.7 | |
|
aBased
on assumed feed consumption of 20 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 500 kg dHighest residue (HR) on a dry weight basis reported in a residue trial conducted according to good agricultural practice |
||||||
| Maximum anticipated dietary exposure: | 0.7 mg/animal/day |
|---|---|
| Equivalent to: | 0.0014 mg/kg bw |
| Equivalent to: | 0.035 ppm in the diet |
| MFL: | 0.04 ppm in the diet |
| Equivalent DDIL: | 0.0012 mg/kg bw |
The MRL for sorghum forage is expressed on a fresh weight basis. The anticipated dietary exposure has been estimated using the actual dry weight residue level observed in an Australian residue trial.
MFL and DDIL are based on actual dose level, animal bodyweight and feed consumption in the dairy cattle transfer study.
Sheep
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL, mg/kg | % DMb | Intake of chemical X, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Fodder
& forage [100% maximum] |
Sorghum
forage (green) [fresh weight] |
100 | 2.5 | 0.035 (HR)d | - | 0.0875 |
| Total | 100 | 2.5 | - | - | 0.0875 | |
|
aBased
on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg dHighest residue (HR) on a dry weight basis reported in a residue trial conducted according to good agricultural practice |
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| Maximum anticipated dietary exposure: | 0.0875 mg/animal/day |
|---|---|
| Equivalent to: | 0.0015 mg/kg bw |
| Equivalent to: | 0.035 ppm in the diet |
| MFL: | 0.04 ppm in the diet |
| Equivalent DDIL: | 0.0017 mg/kg bw |
The MRL for sorghum forage is expressed on a fresh weight basis. The anticipated dietary exposure has been estimated using the actual dry weight residue level observed in an Australian residue trial.
No sheep transfer data are available. The MFL is based on actual dose level, animal bodyweight and feed consumption in the dairy cattle transfer study. The DDIL is calculated from the MFL assuming a 60 kg sheep consuming 2.5 kg DM per day.
Pigs
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL, mg/kg | % DMb | Intake of chemical X, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Cereal grain [100% maximum] | Sorghum | 100 | 2.5 | 0.01 | - | 0.025 |
| Total | 100 | 2.5 | - | - | 0.025 | |
|
aBased
on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg |
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| Maximum anticipated dietary exposure: | 0.025 mg/animal/day |
|---|---|
| Equivalent to: | 0.0004 mg/kg bw |
| Equivalent to: | 0.01 ppm in the diet |
| MFL: | 0.04 ppm in the diet |
| Equivalent DDIL: | 0.0017 mg/kg bw |
No pig transfer data are available. The MFL is based on actual dose level, animal bodyweight and feed consumption in the dairy cattle transfer study. The DDIL is calculated from the MFL assuming a 60 kg pig consuming 2.5 kg DM per day.
Poultry
| Feed group | Feed commodity | % in the diet | Feed intake, kg/animal/daya | MRL, mg/kg | % DMb | Intake of chemical X, mg/animal/dayc |
|---|---|---|---|---|---|---|
| Cereal grain [100% maximum] | Sorghum | 100 | 0.15 | 0.01 | - | 0.0015 |
| Total | 100 | 0.15 | - | - | 0.0015 | |
|
aBased
on assumed feed consumption of 0.15 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 2 kg |
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| Maximum anticipated dietary exposure: | 0.0015 mg/animal/day |
|---|---|
| Equivalent to: | 0.00075 mg/kg bw |
| Equivalent to: | 0.01 ppm in the diet |
| MFL: | 0.01 ppm in the diet |
| Equivalent DDIL: | 0.00065 mg/kg bw |
The MFL and DDILs are based on actual dose level, animal bodyweight and feed consumption in the poultry transfer study.
Attachment 2: Residue Data
Attachment 2 has been removed from this version of the ARDS as it contains commercial-in-confidence data that has not been approved for general release.
Persons wishing to view the data for legitimate residue management purposes should contact the NRA. Release of the data to any nominated person will be at the discretion of the data owner.